A highly versatile convergent/divergent "onion peel" synthetic strategy toward potent multivalent glycodendrimers

Chem Commun (Camb). 2014 Nov 11;50(87):13300-3. doi: 10.1039/c4cc06191h. Epub 2014 Sep 17.

Abstract

Both convergent and divergent strategies for the synthesis of "onion peel" glycodendrimers are reported which resulted in one of the best multivalent ligands known against the virulent factor from a bacterial lectin isolated from Pseudomonas aeruginosa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dendrimers / chemical synthesis*
  • Dendrimers / chemistry*
  • Dendrimers / pharmacology
  • Glycerides / chemical synthesis*
  • Glycerides / chemistry*
  • Glycerides / pharmacology
  • Lectins / chemistry
  • Ligands
  • Molecular Structure
  • Pseudomonas aeruginosa / chemistry
  • Virulence Factors / antagonists & inhibitors

Substances

  • Dendrimers
  • Glycerides
  • Lectins
  • Ligands
  • Virulence Factors