Abstract
A ketone-assisted ruthenium-catalyzed selective amination of xanthones and chromones C-H bonds with sulfonyl azides is described. The reactions proceed efficiently with a broad range of substrates with excellent functional group compatibility. This protocol provides direct access to 1-aminoxanthones, 5-aminochromones, and 5-aminoflavonoid derivatives known to exhibit potent anticancer activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amination
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Azides / chemical synthesis*
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Azides / chemistry
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Azides / pharmacology*
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Catalysis
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Chromones / chemical synthesis*
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Chromones / chemistry
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Chromones / pharmacology*
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Flavonoids / chemical synthesis*
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Flavonoids / chemistry
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Flavonoids / pharmacology*
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Molecular Structure
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Ruthenium / chemistry*
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Xanthones / chemical synthesis*
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Xanthones / chemistry
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Xanthones / pharmacology*
Substances
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Antineoplastic Agents
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Azides
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Chromones
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Flavonoids
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Xanthones
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Ruthenium