Adult myelination: wrapping up neuronal plasticity

Megan O'Rourke; Robert Gasperini; Kaylene M Young

doi:10.4103/1673-5374.137571

Adult myelination: wrapping up neuronal plasticity

Neural Regen Res. 2014 Jul 1;9(13):1261-4. doi: 10.4103/1673-5374.137571.

Authors

Megan O'Rourke¹, Robert Gasperini², Kaylene M Young¹

Affiliations

¹ Menzies Research Institute Tasmania, University of Tasmania, Hobart 7000, Australia.
² Menzies Research Institute Tasmania, University of Tasmania, Hobart 7000, Australia ; The School of Medicine, University of Tasmania, Hobart 7000, Australia.

Abstract

In this review, we outline the major neural plasticity mechanisms that have been identified in the adult central nervous system (CNS), and offer a perspective on how they regulate CNS function. In particular we examine how myelin plasticity can operate alongside neurogenesis and synaptic plasticity to influence information processing and transfer in the mature CNS.

Keywords: NG2; OPC; adult; central nervous system; myelination; neural stem cells; oligodendrocyte; oligodendrogenesis; plasticity; remodelling; synapse.

Publication types

Review