Short-term treatment with the calcineurin inhibitor cyclosporine A decreases HPA axis activity and plasma noradrenaline levels in healthy male volunteers

Abstract

Treatment with the selective calcineurin inhibitor and immunosuppressive drug cyclosporine A (CsA) is associated with neurotoxicity and neurocognitive impairments. Whether and to what extent CsA is inducing alterations of the neuroendocrine status is unknown so far. Therefore, the present study investigated the effect of short-term CsA treatment on hypothalamus-pituitary-adrenal (HPA) axis activity and catecholamine release as well as state anxiety in healthy male subjects. Treatment with CsA significantly reduced plasma concentrations of adrenocorticotropic hormone (ACTH), cortisol, and noradrenaline whereas adrenaline levels and state anxiety remained unaffected. Future studies should analyze the mechanisms of CsA-induced effects on neuroendocrine variables, neurocognitive functions and mood.

Keywords: Calcineurin inhibitor; Cyclosporine A; Neuroendocrine parameters; Neuropsychological changes.