Synthesis and anti-cancer cell activity of pseudo-ginsenoside Rh2

Guangtao Qian; Zhicai Wang; Jinyu Zhao; Dandan Li; Wei Gao; Baohui Wang; Dayuan Sui; Xiangru Qu; Yanping Chen

doi:10.1016/j.steroids.2014.08.021

Synthesis and anti-cancer cell activity of pseudo-ginsenoside Rh2

Steroids. 2014 Dec:92:1-6. doi: 10.1016/j.steroids.2014.08.021. Epub 2014 Sep 10.

Authors

Guangtao Qian¹, Zhicai Wang¹, Jinyu Zhao¹, Dandan Li¹, Wei Gao¹, Baohui Wang¹, Dayuan Sui², Xiangru Qu², Yanping Chen³

Affiliations

¹ Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.
² Department of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China.
³ Department of Chemistry, Jilin University, Changchun, Jilin 130021, China. Electronic address: Ypch2196@sina.com.

PMID: 25218677
DOI: 10.1016/j.steroids.2014.08.021

Abstract

β-d-Glucopyranoside,(3β,12β,20E)-12,25-dihydroxydammar-20(22)-en-3-yl (pseudo-ginsenoside Rh2) and its 20Z-isomer were synthesized from ginsenoside Rh2 under a mild condition, via a simple three-step called acetylation, elimination-addition and saponification. In addition, their activities were evaluated by eight different human tumor cells, compared with ginsenoside Rh2 group. Results indicated that the reaction in the side chain might greatly enhance the anti-proliferative activity of ginsenosides.

Keywords: Ginsenoside; Human tumor cells; Steroid derivatives; Synthesis.

MeSH terms

Antineoplastic Agents / chemistry*
Cell Line, Tumor
Cell Proliferation / drug effects
Ginsenosides / chemical synthesis*
Ginsenosides / chemistry*
Humans
Molecular Structure

Substances

Antineoplastic Agents
Ginsenosides
ginsenoside Rh2