Magnetic nanoparticles-enhanced microwave imaging has been recently proposed as an effective and reliable means to detect breast cancer. Thanks to the nonmagnetic nature of human tissues, the imaging problem corresponds to the retrieval of a weak magnetic anomaly hosted into an unknown nonmagnetic scenario. Hence, properly targeted magnetic nanoparticles in principle allow to avoid false positives and reduce occurrence of false negatives. In this paper, we outline some guidelines for the design of the imaging device based on an optimized measurement configuration. In particular, we determine the nonredundant number of probes and their collocation needed to ensure a reliable solution of the underlying inverse scattering problem. The analysis exploits the spectral properties of the relevant mathematical operators and it is corroborated by reporting numerical results exploiting the phantoms' repository from the University of Wisconsin. It is shown that magnetic nanoparticles-enhanced microwave imaging can reliably detect cancer lesions even using low-complexity arrangements, designed according to the devised guidelines.