Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity

Włodzimierz Luczyński; Wojciech Fendler; Anna Ramatowska; Agnieszka Szypowska; Agnieszka Szadkowska; Wojciech Młynarski; Miron Chumiecki; Przemysława Jarosz-Chobot; Joanna Chrzanowska; Anna Noczyńska; Agnieszka Brandt; Małgorzata Myśliwiec; Barbara Głowińska-Olszewska; Paweł Bernatowicz; Oksana Kowalczuk; Artur Bossowski

doi:10.1155/2014/630712

Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity

Int J Endocrinol. 2014:2014:630712. doi: 10.1155/2014/630712. Epub 2014 Aug 19.

Authors

Włodzimierz Luczyński¹, Wojciech Fendler², Anna Ramatowska³, Agnieszka Szypowska³, Agnieszka Szadkowska², Wojciech Młynarski², Miron Chumiecki⁴, Przemysława Jarosz-Chobot⁴, Joanna Chrzanowska⁵, Anna Noczyńska⁵, Agnieszka Brandt⁶, Małgorzata Myśliwiec⁶, Barbara Głowińska-Olszewska¹, Paweł Bernatowicz⁷, Oksana Kowalczuk⁸, Artur Bossowski¹

Affiliations

¹ Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Bialystok 15-274, Poland.
² Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz 91-738, Poland.
³ Department of Paediatrics, Medical University of Warsaw, Warsaw 01-184, Poland.
⁴ Department of Paediatrics, Paediatric Endocrinology and Diabetology, Medical University of Silesia, in Katowice, Katowice 40-752, Poland.
⁵ Department of Endocrinology and Diabetology of Children and Adolescents, Wroclaw Medical University, Wroclaw 50-268, Poland.
⁶ Department of Paediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Gdansk 80-211, Poland.
⁷ Department of Haematology, Medical University of Bialystok, Bialystok 15-274, Poland.
⁸ Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok 15-274, Poland.

Abstract

The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4-18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P = 0.0003), poor metabolic control (P = 0.0001), and carriage of the A allele of the FTO rs9939609 gene (P = 0.02). Conclusion. Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of the FTO gene adds to that of female gender and poor metabolic control. This trial is registered with ClinicalTrials.gov (NCT01279161).

Associated data

ClinicalTrials.gov/NCT01279161