The possible involvement of microRNAs in preeclampsia and gestational diabetes mellitus

Nir Pillar; Liron Yoffe; Moshe Hod; Noam Shomron

doi:10.1016/j.bpobgyn.2014.04.021

The possible involvement of microRNAs in preeclampsia and gestational diabetes mellitus

Best Pract Res Clin Obstet Gynaecol. 2015 Feb;29(2):176-82. doi: 10.1016/j.bpobgyn.2014.04.021. Epub 2014 Aug 21.

Authors

Nir Pillar¹, Liron Yoffe¹, Moshe Hod², Noam Shomron³

Affiliations

¹ Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
² Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel; Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel.
³ Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: nshomron@post.tau.ac.il.

PMID: 25214435
DOI: 10.1016/j.bpobgyn.2014.04.021

Abstract

Great obstetrical syndromes is a collective name for several complications of pregnancy that affect >15% of pregnancies. They may confer adverse pregnancy outcomes and maternal and fetal morbidity, and require close medical monitoring and treatment. The etiology, pathogenesis, and outcome of these syndromes are obscure in the majority of cases. All appear during mid-to-late pregnancy with no reliable biomarkers for early detection and possibly prevention at present. This article focuses on the quest for early reliable markers for preeclampsia and gestational diabetes mellitus (GDM) development, mainly on the involvement of microRNA in the pathogenesis and its possible role as an early biomarker for disease development.

Keywords: biomarker; early detection; gestational diabetes mellitus; microRNA; preeclampsia.

Publication types

Review

MeSH terms

Diabetes, Gestational / diagnosis
Diabetes, Gestational / genetics*
Early Diagnosis
Female
Genetic Markers
Humans
MicroRNAs / metabolism*
Pre-Eclampsia / diagnosis
Pre-Eclampsia / genetics*
Pregnancy

Substances

Genetic Markers
MicroRNAs