Haptoglobin genotyping of Vietnamese: global distribution of HP del, complete deletion allele of the HP gene

Mikiko Soejima; Tetsuro Agusa; Hisato Iwata; Junko Fujihara; Takashi Kunito; Haruo Takeshita; Vi Thi Mai Lan; Tu Binh Minh; Shin Takahashi; Pham Thi Kim Trang; Pham Hung Viet; Shinsuke Tanabe; Yoshiro Koda

doi:10.1016/j.legalmed.2014.08.004

Haptoglobin genotyping of Vietnamese: global distribution of HP del, complete deletion allele of the HP gene

Leg Med (Tokyo). 2015 Jan;17(1):14-6. doi: 10.1016/j.legalmed.2014.08.004. Epub 2014 Aug 27.

Authors

Affiliations

¹ Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume, Japan.
² Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
³ Department of Legal Medicine, Shimane University Faculty of Medicine, Enya 89-1, Izumo 693-8501, Japan.
⁴ Department of Environmental Sciences, Faculty of Science, Shinshu University, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
⁵ Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, T3 Building, 334 Nguyen Trai Street, Thanh Xuan District, Hanoi, Viet Nam.
⁶ Department of Environmental Conservation, Faculty of Agriculture, Ehime University, Tarumi 3-5-7, Matsuyama 790-8566, Japan.
⁷ Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume, Japan. Electronic address: ykoda@med.kurume-u.ac.jp.

PMID: 25212669
DOI: 10.1016/j.legalmed.2014.08.004

Abstract

The haptoglobin (HP) gene deletion allele (HP(del)) is responsible for anhaptoglobinemia and a genetic risk factor for anaphylaxis reaction after transfusion due to production of the anti-HP antibody. The distribution of this allele has been explored by several groups including ours. Here, we studied the frequency of HP(del) in addition to the distribution of common HP genotypes in 293 Vietnamese. The HP(del) was encountered with the frequency of 0.020. The present result suggested that this deletion allele is restricted to East and Southeast Asians. Thus, this allele seems to be a potential ancestry informative marker for these populations.

Keywords: Anaphylaxis; Ancestry informative marker; Gene deletion; Geographic distribution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Anaphylaxis / genetics
Asian People / genetics*
Female
Gene Deletion*
Genetic Predisposition to Disease
Genotype
Haptoglobins / deficiency*
Haptoglobins / genetics*
Humans
Male
Real-Time Polymerase Chain Reaction
Transfusion Reaction
Vietnam

Substances

Haptoglobins