Advanced glycation end products inhibitors from Alpinia zerumbet rhizomes

Jamnian Chompoo; Atul Upadhyay; Wataru Kishimoto; Tadahiro Makise; Shinkichi Tawata

doi:10.1016/j.foodchem.2011.04.034

Advanced glycation end products inhibitors from Alpinia zerumbet rhizomes

Food Chem. 2011 Dec 1;129(3):709-15. doi: 10.1016/j.foodchem.2011.04.034. Epub 2011 Apr 20.

Authors

Jamnian Chompoo¹, Atul Upadhyay², Wataru Kishimoto³, Tadahiro Makise⁴, Shinkichi Tawata⁵

Affiliations

¹ Department of Bioscience and Biotechnology, The United Graduate School of Agricultural Science, Kagoshima University, Kagoshima 890-0065, Japan. Electronic address: mcmine56@yahoo.com.
² Department of Bioscience and Biotechnology, The United Graduate School of Agricultural Science, Kagoshima University, Kagoshima 890-0065, Japan. Electronic address: atul616@yahoo.com.
³ Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Senbaru 1, Nishihara-cho, Okinawa 903-0219, Japan. Electronic address: K098963@eve.u-ryukyu.ac.jp.
⁴ Life Up Clinic, 750 Minamiuehara, Nakagusuku, Okinawa 901-2424, Japan. Electronic address: dr@drmakise.com.
⁵ Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Senbaru 1, Nishihara-cho, Okinawa 903-0219, Japan. Electronic address: b986097@agri.u-ryukyu.ac.jp.

PMID: 25212289
DOI: 10.1016/j.foodchem.2011.04.034

Abstract

Advanced glycation end products (AGEs) are major factors responsible for the complication of diabetes. The present study was carried out to investigate the inhibitory activities on fructosamine adduct and α-dicarbonyl formations by hexane extracts of various parts of Alpinia zerumbet. Furthermore, we isolated two previously known compounds, namely 5,6-dehydrokawain (DK) and dihydro-5,6-dehydrokawain (DDK). 8(17),12-Labdadiene-15,16-dial (labdadiene) was isolated for the first time from the rhizome of A. zerumbet. The results showed that labdadiene (IC50=51.06μg/mL) had similar activity to rutin and quercetin against fructosamine adduct. The inhibition of α-dicarbonyl compounds formation by labdadiene was significantly higher than that of DK and DDK. Our results indicate that labdadiene is a potent antiglycation agent which was found to inhibit AGEs formation in three different steps in the pathway. These data indicate that labdadiene could be used to prevent glycation-associated complications in diabetes.

Keywords: 5,6-Dehydrokawain; 8(17),12-Labdadiene-15,16-dial; Advanced glycation end products (AGEs); Alpinia zerumbet; Diabetes; Dihydro-5,6-dehydrokawain.