Interaction between the antimicrobial peptide Aurein 1.2 dimer and mannans

Amino Acids. 2014 Nov;46(11):2627-31. doi: 10.1007/s00726-014-1832-x. Epub 2014 Sep 11.

Abstract

We have previously described the structure and the ability of a dimeric analog of the antimicrobial peptide Aurein 1.2 to aggregate Candida albicans. In this study, circular dichroism and fluorescence spectroscopy data showed that this aggregation is related to the interaction between the peptide and mannans, the main component of yeast cell wall. In this context, we propose a model in which dimers interact with the polysaccharide leading to cells aggregation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antimicrobial Cationic Peptides / chemistry*
  • Candida albicans / metabolism
  • Cell Wall / metabolism
  • Circular Dichroism
  • Mannans / chemistry*
  • Molecular Weight
  • Polymers / chemistry
  • Protein Multimerization
  • Protein Structure, Secondary
  • Saccharomyces cerevisiae / metabolism
  • Spectrometry, Fluorescence

Substances

  • Antifungal Agents
  • Antimicrobial Cationic Peptides
  • Mannans
  • Polymers
  • aurein 1.2 peptide