Effect of a Tibetan herbal mixture on microvascular endothelial function, heart rate variability and biomarkers of inflammation, clotting and coagulation

Eur J Prev Cardiol. 2015 Aug;22(8):1043-5. doi: 10.1177/2047487314544985. Epub 2014 Sep 10.

Abstract

In this 6-week prospective, randomized, placebo-controlled and double-blind study, we investigated the effects of a natural herbal remedy based on a recipe from Tibet (Padma® 28), on microvascular endothelial function, heart rate variability and biomarkers of inflammation, clotting and coagulation in 80 coronary artery disease (CAD) patients (age 66 ± 8 years) on guideline-based medication for secondary prevention. We found no significant effects of Padma 28 and conclude that the addition of Padma 28 to guideline-based secondary prevention treatment of CAD did not lead to significant effects on important surrogate markers in elderly male CAD patients.

Trial registration: ClinicalTrials.gov NCT01581034.

Keywords: EndoPat; Padma 28; autonomic nervous tone; biomarkers; coronary artery disease; microvascular endothelial function.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood
  • Blood Coagulation / drug effects*
  • Blood Coagulation Tests
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / drug therapy*
  • Coronary Artery Disease / physiopathology
  • Double-Blind Method
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / physiopathology
  • Heart Rate / drug effects*
  • Humans
  • Inflammation Mediators / blood*
  • Male
  • Microcirculation / drug effects*
  • Microvessels / drug effects*
  • Microvessels / physiopathology
  • Middle Aged
  • Phytotherapy
  • Plant Extracts / therapeutic use*
  • Plants, Medicinal
  • Prospective Studies
  • Secondary Prevention
  • Switzerland
  • Time Factors
  • Treatment Outcome

Substances

  • Biomarkers
  • Inflammation Mediators
  • Plant Extracts
  • Padma 28

Associated data

  • ClinicalTrials.gov/NCT01581034