Features of adult neurogenesis and neurochemical signaling in the Cherry salmon Oncorhynchus masou brain

Evgeniya V Pushchina; Dmitry K Obukhov; Anatoly A Varaksin

doi:10.3969/j.issn.1673-5374.2013.01.002

Features of adult neurogenesis and neurochemical signaling in the Cherry salmon Oncorhynchus masou brain

Neural Regen Res. 2013 Jan 5;8(1):13-23. doi: 10.3969/j.issn.1673-5374.2013.01.002.

Authors

Evgeniya V Pushchina¹, Dmitry K Obukhov², Anatoly A Varaksin¹

Affiliations

¹ Laboratory of Cytophysiology, Institute of Marine Biology, Far East Branch, Russian Academy of Sciences, Vladivostok 690059, Russia.
² St. Petersburg State University, St. Petersburg 199034, Russia.

PMID: 25206367
PMCID: PMC4107501
DOI: 10.3969/j.issn.1673-5374.2013.01.002

Abstract

We investigated the distribution of gamma aminobutyric acid, tyrosine hydroxylase and nitric oxide-producing elements in a cherry salmon Oncorhynchus masou brain at various stages of postnatal ontogenesis by immunohistochemical staining and histochemical staining. The periventricular region cells exhibited the morphology of neurons and glia including radial glia-like cells and contained several neurochemical substances. Heterogeneous populations of tyrosine hydroxylase-, gamma aminobutyric acid-immunoreactive, as well as nicotinamide adenine dinucleotide phosphate diaphorase-positive cells were observed in proliferating cell nuclear antigen-immunoreactive proliferative zones in periventricular area of diencephalon, central grey layer of dorsomedial tegmentum, medulla and spinal cord. Immunolocalization of Pax6 in the cherry salmon brain revealed a neuromeric construction of the brain at various stages of postnatal ontogenesis, and this was confirmed by tyrosine hydroxylase and gamma aminobutyric acid labeling.

Keywords: NADPH-diaphorase; Pax6; adult neurogenesis; development; gamma aminobutyric acid; grant-supported paper; migration; neural regeneration; neurogenesis; neuroregeneration; neurotransmitter signaling; proliferation; teleostei; tyrosine hydroxylase.