Copper-catalyzed phosphorylation of sp(2) C-H bonds

Chem Commun (Camb). 2014 Oct 28;50(84):12718-21. doi: 10.1039/c4cc06246a.

Abstract

The phosphorylation of the ortho C-H bonds in benzamides containing an 8-aminoquinoline moiety as a bidentate directing group with H-phosphonates using copper as a catalyst under mild temperature conditions is described. This method shows high functional group compatibility and selectively gives mono-substituted products.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoquinolines / chemistry
  • Benzamides / chemistry
  • Carbon / chemistry
  • Carboxylic Acids / chemistry
  • Catalysis
  • Copper / chemistry*
  • Hydrogen / chemistry
  • Phosphorylation
  • Temperature

Substances

  • Aminoquinolines
  • Benzamides
  • Carboxylic Acids
  • benzamide
  • Carbon
  • Copper
  • Hydrogen
  • 8-aminoquinoline