Abstract
The phosphorylation of the ortho C-H bonds in benzamides containing an 8-aminoquinoline moiety as a bidentate directing group with H-phosphonates using copper as a catalyst under mild temperature conditions is described. This method shows high functional group compatibility and selectively gives mono-substituted products.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoquinolines / chemistry
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Benzamides / chemistry
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Carbon / chemistry
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Carboxylic Acids / chemistry
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Catalysis
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Copper / chemistry*
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Hydrogen / chemistry
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Phosphorylation
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Temperature
Substances
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Aminoquinolines
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Benzamides
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Carboxylic Acids
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benzamide
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Carbon
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Copper
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Hydrogen
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8-aminoquinoline