FAL1ing inside an amplicon

Cancer Cell. 2014 Sep 8;26(3):303-304. doi: 10.1016/j.ccr.2014.08.009.

Abstract

Frequently amplified regions of the cancer genome contain well-known oncogenes. In this issue of Cancer Cell, Hu and colleagues discover that FAL1, a long noncoding RNA is encoded in one of these regions. FAL1 acts as an oncogene by stabilizing BMI1, which results in the repression of CDKN1A expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cyclin-Dependent Kinase Inhibitor p21 / genetics*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Neoplasms, Glandular and Epithelial / genetics*
  • Ovarian Neoplasms / genetics*
  • Polycomb Repressive Complex 1 / metabolism*
  • RNA, Long Noncoding / physiology*

Substances

  • BMI1 protein, human
  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • RNA, Long Noncoding
  • Polycomb Repressive Complex 1