Decoys and cardiovascular development: CXCR7 and regulation of adrenomedullin signaling

Kelly L Betterman; Natasha L Harvey

doi:10.1016/j.devcel.2014.08.021

Decoys and cardiovascular development: CXCR7 and regulation of adrenomedullin signaling

Dev Cell. 2014 Sep 8;30(5):490-1. doi: 10.1016/j.devcel.2014.08.021.

Authors

Kelly L Betterman¹, Natasha L Harvey²

Affiliations

¹ Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide 5000, Australia.
² Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide 5000, Australia; School of Medicine, University of Adelaide, Adelaide 5000, Australia. Electronic address: natasha.harvey@unisa.edu.au.

PMID: 25203203
DOI: 10.1016/j.devcel.2014.08.021

Abstract

Decoy receptors have ligand binding capacity but, in contrast to cognate receptors, do not initiate typical downstream signaling cascades. In this issue of Developmental Cell, Klein and colleagues (2014) demonstrate that CXCR7 acts as a decoy receptor for adrenomedullin, a peptide hormone with key roles in cardiovascular development.

Publication types

Comment

MeSH terms

Adrenomedullin / metabolism*
Animals
Female
Gene Expression Regulation, Developmental*
Heart / embryology*
Humans
Lymphatic Vessels / embryology*
Male
Receptors, CXCR / physiology*

Substances

Cmkor1 protein, mouse
Receptors, CXCR
Adrenomedullin