Inflammation: IL-36 has proinflammatory effects in skin but not in joints

Damien Dietrich; Cem Gabay

doi:10.1038/nrrheum.2014.156

Inflammation: IL-36 has proinflammatory effects in skin but not in joints

Nat Rev Rheumatol. 2014 Nov;10(11):639-40. doi: 10.1038/nrrheum.2014.156. Epub 2014 Sep 9.

Authors

Damien Dietrich¹, Cem Gabay¹

Affiliation

¹ Division of Rheumatology, University Hospitals of Geneva, 26 Avenue de Beau-Séjour, 1211 Geneva 14, Switzerland.

PMID: 25201385
DOI: 10.1038/nrrheum.2014.156

Abstract

Given the known involvement of IL-36 in psoriasis it might be surprising that the latest mouse models show that inhibiting IL-36 signalling does not alter the course of inflammatory arthritis. Can we now add IL-36 to the list of inflammatory mediators that are not viable DMARD targets?

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Arthritis / immunology
Arthritis, Experimental / immunology*
Dermatitis / immunology
Humans
Inflammation / immunology
Interleukin-1 / immunology*
Mice
Psoriasis / immunology*
Receptors, Interleukin / immunology
Receptors, Interleukin-1 / immunology
Skin / immunology
Synovial Membrane / immunology
Synovitis / immunology*

Substances

IL-1F8 protein, mouse
IL1F9 protein, mouse
Interleukin-1
Receptors, Interleukin
Receptors, Interleukin-1
interleukin 1F6, mouse
interleukin 36, human
interleukin-36 receptor, human
interleukin-36 receptor, mouse