Abstract
Cu(I)-catalyzed azide-alkyne cyclization (CuAAC) is the paradigmatic click reaction of continuous interest. Especially fluorogenic and FRET probes have become indispensable tools for life sciences. Here, we present a fluorescent alkyne for monitoring CuAAC, which undergoes a bathochromic shift upon reaction. Application in single-molecule and catalysis research is foreseen.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry
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Azides / chemistry
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Boron Compounds / chemistry
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Catalysis
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Click Chemistry*
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Copper / chemistry
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Crystallography, X-Ray
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Cyclization
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Fluorescence Resonance Energy Transfer
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Fluorescent Dyes / chemistry*
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Molecular Conformation
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Alkynes
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Azides
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Boron Compounds
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Fluorescent Dyes
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Copper