Synthesis of antifungal evaluation of 2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones

Chem Pharm Bull (Tokyo). 2014;62(11):1119-24. doi: 10.1248/cpb.c14-00527. Epub 2014 Sep 5.

Abstract

2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones and 2H-[1,2,3]triazolo[4,5-g]quinoline-4,9-diones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Many of those synthesized showed potent antifungal activity. Compounds 3a, 3b, 3g, and 3h completely inhibited the growth of all fungal species tested at the MIC level of 0.8-12.5 µg/mL. The results suggest that 2H-[1,2,3]triazolo[4,5-g]isoquinoline-4,9-diones could be antifungal agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology*
  • Drug Design
  • Fungi / drug effects*
  • Humans
  • Isoquinolines / chemical synthesis
  • Isoquinolines / chemistry*
  • Isoquinolines / pharmacology*
  • Microbial Sensitivity Tests
  • Mycoses / drug therapy
  • Structure-Activity Relationship
  • Triazoles / chemical synthesis
  • Triazoles / chemistry*
  • Triazoles / pharmacology*

Substances

  • Antifungal Agents
  • Isoquinolines
  • Triazoles
  • isoquinoline