The role of cystatin C in the prognosis of adverse outcomes after the coronary artery bypass graft surgery during hospitalisation

Kristina S Shafranskaya; Vasiliy V Kashtalap; Olga V Gruzdeva; Anton G Kutikhin; Olga L Barbarash; Leonid S Barbarash

doi:10.1016/j.hlc.2014.07.060

The role of cystatin C in the prognosis of adverse outcomes after the coronary artery bypass graft surgery during hospitalisation

Heart Lung Circ. 2015 Feb;24(2):193-9. doi: 10.1016/j.hlc.2014.07.060. Epub 2014 Jul 24.

Authors

Kristina S Shafranskaya¹, Vasiliy V Kashtalap², Olga V Gruzdeva¹, Anton G Kutikhin³, Olga L Barbarash⁴, Leonid S Barbarash⁵

Affiliations

¹ Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, 650002, Sosnovy Bulvar 6, Russia.
² Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, 650002, Sosnovy Bulvar 6, Russia; Department of Cardiology and Cardiovascular Surgery, Kemerovo State Medical Academy, Kemerovo, 650002, Sosnovy Bulvar 6, Russia.
³ Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, 650002, Sosnovy Bulvar 6, Russia; Department of Epidemiology, Kemerovo State Medical Academy, Kemerovo, 650029, Voroshilova Street 22a, Russia; Central Research Laboratory, Kemerovo State Medical Academy, Kemerovo, 650029, Voroshilova Street 22a, Russia.
⁴ Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, 650002, Sosnovy Bulvar 6, Russia; Department of Cardiology and Cardiovascular Surgery, Kemerovo State Medical Academy, Kemerovo, 650002, Sosnovy Bulvar 6, Russia. Electronic address: barbol@cardio.kem.ru.
⁵ Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, 650002, Sosnovy Bulvar 6, Russia; Department of Cardiology and Cardiovascular Surgery, Kemerovo State Medical Academy, Kemerovo, 650002, Sosnovy Bulvar 6, Russia; Kemerovo Cardiological Centre, Kemerovo, 650002, Sosnovy Bulvar 6, Russia.

PMID: 25194959
DOI: 10.1016/j.hlc.2014.07.060

Abstract

Background: This study has been aimed to assess clinical significance of cystatin C in the prognosis of a risk of hospital complications among the patients with coronary artery disease CAD who have undergone coronary artery bypass surgery (CABG).

Methods: We have recruited 719 consecutive Caucasian (Russian) patients who underwent CABG in 2011-2012.

Results: No statistically significant differences in the serum creatinine concentration (sCr) and glomerular filtration rate before and seven days after the surgery have been found among the patients belonging to different EuroSCORE risk groups. A statistically significant elevation of serum cystatin C concentration (sCC) before and seven days after the surgery has been demonstrated in EuroSCORE medium- and high-risk groups in comparison with the low-risk group. In addition, we have revealed increased pre-surgical levels of sCC in patients who had died earlier than seven days after CABG. Regarding the cardiovascular complications, a statistically significant elevation of sCC has been observed in patients with and without myocardial infarction (MI), stroke, or acute kidney injury (AKI) in the postoperative period.

Conclusions: We suggest that the determination of sCC before and after CABG surgery may help in the prognosis of adverse cardiovascular and renal outcomes after the CABG surgery.

Keywords: Adverse outcomes; Complications; Coronary artery bypass graft surgery; Coronary artery disease; Cystatin C.; EuroSCORE.

Publication types

Clinical Trial
Multicenter Study

MeSH terms

Adult
Aged
Coronary Artery Bypass*
Coronary Artery Disease / blood*
Coronary Artery Disease / surgery*
Cystatin C / blood*
Female
Hospitalization*
Humans
Male
Middle Aged
Postoperative Complications / blood*
Postoperative Complications / diagnosis
Postoperative Complications / etiology
Prognosis

Substances

CST3 protein, human
Cystatin C