Recombination in the evolution of human bocavirus

Alexander I Tyumentsev; Nina V Tikunova; Artem Yu Tikunov; Igor V Babkin

doi:10.1016/j.meegid.2014.08.026

Recombination in the evolution of human bocavirus

Infect Genet Evol. 2014 Dec:28:11-4. doi: 10.1016/j.meegid.2014.08.026. Epub 2014 Sep 2.

Authors

Alexander I Tyumentsev¹, Nina V Tikunova¹, Artem Yu Tikunov¹, Igor V Babkin²

Affiliations

¹ Laboratory of Molecular Microbiology, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
² Laboratory of Molecular Microbiology, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia. Electronic address: i_babkin@mail.ru.

PMID: 25193564
DOI: 10.1016/j.meegid.2014.08.026

Abstract

Whole genome sequencing of Novosibirsk human bocavirus (HBoV) isolates has detected an isolate that emerged via recombination between HBoV3 and HBoV4 genotypes. The recombination site is located between regions with abnormally low and abnormally high GC contents in the genome. This site is a bocavirus recombination hotspot and coincides with one of two parvovirus recombination hotspots. The Novosibirsk recombinant isolate, which is similar to a previously studied isolate from Thailand, utilizes the strategy of borrowing ORF3, which encodes structural proteins, of a rare genotype HBoV4. The role of recombination in HBoV evolution is discussed.

Keywords: Complete genome; Human bocavirus; Recombination; Virus evolution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Composition
Evolution, Molecular*
Genome, Viral
Genotype
Human bocavirus / genetics*
Human bocavirus / isolation & purification
Humans
Infant
Male
Open Reading Frames
Parvoviridae Infections / virology*
Reassortant Viruses*
Recombination, Genetic*
Sequence Analysis, DNA