Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases

Expert Rev Vaccines. 2015 Jan;14(1):21-35. doi: 10.1586/14760584.2015.955478. Epub 2014 Sep 5.

Abstract

Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world's poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere.

Keywords: Brugia malayi; EID; EpiMatrix; JanusMatrix; MHC; NTD; T cell; TCR; computational vaccinology; filarial; immunogenicity; immunoinformatics; immunomics; tregitope.

Publication types

  • Research Support, American Recovery and Reinvestment Act
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Communicable Diseases, Emerging / epidemiology*
  • Communicable Diseases, Emerging / prevention & control*
  • Computational Biology / methods*
  • Genomics / methods*
  • Humans
  • Neglected Diseases / immunology*
  • Neglected Diseases / prevention & control*
  • Tropical Climate
  • Vaccines / genetics
  • Vaccines / immunology
  • Vaccines / isolation & purification*

Substances

  • Vaccines