High-risk human papillomavirus in Galicia, Spain: prevalence and evaluation of the sample representativeness

Scand J Infect Dis. 2014 Nov;46(11):737-44. doi: 10.3109/00365548.2014.930966. Epub 2014 Sep 5.

Abstract

Background: The prevalence of high-risk genotypes of the human papillomavirus (HR-HPV) in Galicia remained unknown before the introduction of the HPV vaccine. The objective of this study was to estimate this prevalence in non-vaccinated women when vaccination against HR-HPV started. Sample representativeness was also evaluated.

Methods: Female volunteers aged 16-64 years, residents in Galicia, Spain, completed a questionnaire and provided biological samples for a virological study and for cytology. The sample was weighted; prevalence rates were estimated and are shown with 95% confidence intervals.

Results: Virological results were available for 1703 women. HR-HPV prevalence was 10.1%, decreasing notably at ages above 30 years. HPV-16 was the most frequent genotype and 3.6% of women were infected by more than one genotype. No adjustment was necessary to generalize the results of the study.

Conclusions: In Galicia in 2009 there would be 96 400 women aged 16-64 years infected with HR-HPV. It is possible to estimate HR-HPV prevalence in a population starting from a volunteer sample.

Keywords: Adult; human papilloma virus; prevalence; sexually transmitted diseases.

MeSH terms

  • Adolescent
  • Adult
  • Coinfection / epidemiology
  • Cross-Sectional Studies
  • Female
  • Humans
  • Middle Aged
  • Papillomaviridae
  • Papillomavirus Infections / epidemiology*
  • Prevalence
  • Risk
  • Sexually Transmitted Diseases, Viral / epidemiology*
  • Spain / epidemiology
  • Surveys and Questionnaires
  • Young Adult