Postpartum Treatment With Immunoglobulin Does Not Prevent Relapses of Multiple Sclerosis in the Mother

Health Care Women Int. 2015;36(10):1072-80. doi: 10.1080/07399332.2014.948627. Epub 2014 Oct 30.

Abstract

Multiple sclerosis (MS) is a chronic, neurological, immune-mediated disease that can worsen in the postpartum period. There is no consensus on the use of immunoglobulin for prevention of disease relapses after delivery. We have shown that the controversial beneficial effect of immunoglobulin given immediately after birth could not be observed in patients with MS.

MeSH terms

  • Adult
  • Case-Control Studies
  • Female
  • Humans
  • Immunoglobulins, Intravenous / pharmacology
  • Immunoglobulins, Intravenous / therapeutic use*
  • Mothers*
  • Multiple Sclerosis / complications
  • Multiple Sclerosis / drug therapy*
  • Multiple Sclerosis / physiopathology
  • Multiple Sclerosis, Relapsing-Remitting / prevention & control*
  • Postpartum Period / drug effects*
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Pregnancy Complications / immunology
  • Pregnancy Outcome
  • Puerperal Disorders / prevention & control
  • Recurrence
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome

Substances

  • Immunoglobulins, Intravenous