A new daphnane diterpenoid from Excoecaria venenata with inhibitory effect on human leukaemia HL-60 cells

Nat Prod Res. 2015;29(6):524-8. doi: 10.1080/14786419.2014.953498. Epub 2014 Sep 3.

Abstract

A new daphnane diterpenoid, venenatin (1), along with six known compounds, was isolated from the aerial parts of Excoecaria venenata. The structure of 1 was elucidated on the basis of extensive spectroscopic analysis. Compound 1 exhibited growth inhibitory effect on human leukaemia HL-60 cell line with IC50 value of 28.10 μM.

Keywords: Excoecaria venenata; HL-60; daphnane diterpenoid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • China
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Drug Screening Assays, Antitumor
  • Euphorbiaceae / chemistry*
  • HL-60 Cells
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Plant Components, Aerial / chemistry*

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • venenatine