Abstract
A new daphnane diterpenoid, venenatin (1), along with six known compounds, was isolated from the aerial parts of Excoecaria venenata. The structure of 1 was elucidated on the basis of extensive spectroscopic analysis. Compound 1 exhibited growth inhibitory effect on human leukaemia HL-60 cell line with IC50 value of 28.10 μM.
Keywords:
Excoecaria venenata; HL-60; daphnane diterpenoid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Antineoplastic Agents, Phytogenic / pharmacology*
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China
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Euphorbiaceae / chemistry*
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HL-60 Cells
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Plant Components, Aerial / chemistry*
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Diterpenes
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venenatine