Combined optical and electronic sensing of epithelial cells using planar organic transistors

Marc Ramuz; Adel Hama; Miriam Huerta; Jonathan Rivnay; Pierre Leleux; Róisín M Owens

doi:10.1002/adma.201401706

Combined optical and electronic sensing of epithelial cells using planar organic transistors

Adv Mater. 2014 Nov 5;26(41):7083-90. doi: 10.1002/adma.201401706. Epub 2014 Sep 1.

Authors

Marc Ramuz¹, Adel Hama, Miriam Huerta, Jonathan Rivnay, Pierre Leleux, Róisín M Owens

Affiliation

¹ Department of Bioelectronics, Ecole Nationale Supérieure des Mines CMP-EMSE, MOC, 880 avenue de Mimet, 13541, Gardanne, France.

Abstract

A planar, conducting-polymer-based transistor for combined optical and electronic monitoring of live cells provides a unique platform for monitoring the health of cells in vitro. Monitoring of MDCK-I epithelial cells over several days is shown, along with a demonstration of the device for toxicology studies, of use in future drug discovery or diagnostics applications.

Keywords: MDCK cells; barrier tissue; conducting polymers; poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS); tight junctions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dogs
Electrical Equipment and Supplies*
Epithelial Cells / cytology*
Madin Darby Canine Kidney Cells
Optical Devices*
Polystyrenes / chemistry*
Thiophenes / chemistry*
Transistors, Electronic*

Substances

Polystyrenes
Thiophenes
poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)