Croton insularis introduces the seco-casbane class with EBC-329 and the first casbane endoperoxide EBC-324

Lidiya A Maslovskaya; Andrei I Savchenko; Elizabeth H Krenske; Victoria A Gordon; Paul W Reddell; Carly J Pierce; Peter G Parsons; Craig M Williams

doi:10.1039/c4cc05413j

Croton insularis introduces the seco-casbane class with EBC-329 and the first casbane endoperoxide EBC-324

Chem Commun (Camb). 2014 Oct 21;50(82):12315-7. doi: 10.1039/c4cc05413j.

Authors

Lidiya A Maslovskaya¹, Andrei I Savchenko, Elizabeth H Krenske, Victoria A Gordon, Paul W Reddell, Carly J Pierce, Peter G Parsons, Craig M Williams

Affiliation

¹ QIMR Berghofer Medical Research Institute, PO Royal Brisbane Hospital, Brisbane, 4029, Queensland, Australia.

PMID: 25178400
DOI: 10.1039/c4cc05413j

Abstract

Investigation of Croton insularis afforded the first in class seco-casbane diterpene, EBC-329. A highly oxidised casbane, EBC-324, was also isolated. The structural motif within EBC-324, which consists of an epoxidised hemi-acetal endoperoxide, is new to the casbane family.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Croton / chemistry*
Diterpenes / chemistry*
Diterpenes / isolation & purification
Magnetic Resonance Spectroscopy
Peroxides / chemistry*
Peroxides / isolation & purification

Substances

Diterpenes
Peroxides