Polymorphism in the 5ꞌ-UTR of the insulin-like growth factor I gene associated with production traits in Chinese cattle

Genet Mol Res. 2014 Aug 29;13(3):6899-905. doi: 10.4238/2014.August.29.12.

Abstract

The insulin-like growth factor I (IGF-1) gene plays important roles in the growth and body composition of animals. Serum IGF1 concentration has been associated with growth traits in many livestock species. We found a polymorphism of cattle IGF1-TasI locus and analyzed the distribution of alleles in three cattle breeds, including Qinchuan, Nanyang, and Chinese Holstein. PCR-RFLP analysis showed that allele A was the dominant allele. The frequencies of allele A varied from 0.84 to 0.97. Distributions of genotypic and allelic frequencies were significantly different among breeds. Polymorphism of the IGF1 gene was significantly affecting hucklebone width at 6 months in the Nanyang breed and protein and fat yield of the third lactation in Chinese Holstein cattle. Individuals with allele C had a significantly higher performance in production traits.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5' Untranslated Regions / genetics*
  • Alleles
  • Animals
  • Animals, Newborn
  • Body Composition / genetics
  • Body Weights and Measures
  • Cattle / classification
  • Cattle / genetics*
  • Cattle / growth & development
  • China
  • Female
  • Gene Frequency
  • Genetic Association Studies / methods
  • Genotype
  • Insulin-Like Growth Factor I / genetics*
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide*
  • Species Specificity
  • Time Factors

Substances

  • 5' Untranslated Regions
  • Insulin-Like Growth Factor I