Abstract
The effects of administering the selenocompounds, sodium selenite, methylseleninic acid (MSA), and seleno-L-methionine (SeMet) on glucose tolerance were compared in the nicotinamide (NA) and streptozotocin (STZ)-induced diabetic mouse model. ICR mice were intraperitoneally treated twice with STZ (100 mg/kg) 15 min after an injection of NA (120 mg/kg) at a 1-d interval. Non-fasting blood glucose levels were then monitored weekly while orally administering the selenocompounds at 158 µg Se/kg body weight with free access to a selenium-deficient diet for 5 weeks. The mean body weights of NA/STZ-induced diabetic mice were partly restored by the administration of selenocompounds, while SeMet led to a higher selenium content and glutathione peroxidase 1 activity in the pancreas. Non-fasting and oral glucose tolerance-tested blood glucose levels, which were elevated by NA/STZ, were significantly suppressed by the administration of SeMet. These results suggest that SeMet may improve glucose tolerance in a NA/STZ-induced mild diabetic mouse model by increasing bioavailability in the pancreas.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Availability
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Blood Glucose / drug effects
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Diabetes Mellitus, Experimental / blood
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Diabetes Mellitus, Experimental / chemically induced
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Diabetes Mellitus, Experimental / drug therapy*
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Diabetes Mellitus, Experimental / metabolism
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Glucose Tolerance Test
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Glutathione Peroxidase / metabolism
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Glutathione Peroxidase GPX1
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Hypoglycemic Agents* / pharmacokinetics
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Hypoglycemic Agents* / pharmacology
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Hypoglycemic Agents* / therapeutic use
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Liver / metabolism
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Male
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Mice, Inbred ICR
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Niacinamide
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Organoselenium Compounds* / pharmacokinetics
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Organoselenium Compounds* / pharmacology
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Organoselenium Compounds* / therapeutic use
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Pancreas / metabolism
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Selenomethionine* / pharmacokinetics
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Selenomethionine* / pharmacology
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Selenomethionine* / therapeutic use
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Sodium Selenite* / pharmacokinetics
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Sodium Selenite* / pharmacology
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Sodium Selenite* / therapeutic use
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Streptozocin
Substances
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Blood Glucose
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Hypoglycemic Agents
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Organoselenium Compounds
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Niacinamide
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Streptozocin
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Selenomethionine
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methylselenic acid
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Glutathione Peroxidase
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Sodium Selenite
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Glutathione Peroxidase GPX1
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Gpx1 protein, mouse