Abstract
We examined the effects of heptamethoxyflavone (HMF), a citrus flavonoid on inflammatory bone resorption. HMF suppressed the osteoclast formation and PGE2 production induced by IL-1. In mouse calvarial organ cultures, HMF attenuated the bone resorption elicited by LPS. HMF suppressed bone resorption in the mandibular alveolar bone. HMF may protect against inflammatory bone loss such as periodontal disease.
Keywords:
heptamethoxyflavone; inflammatory bone loss; osteoclast; periodontal disease.
MeSH terms
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Alveolar Bone Loss / metabolism
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Alveolar Bone Loss / pathology
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Alveolar Bone Loss / prevention & control*
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Animals
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Animals, Newborn
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Citrus / chemistry*
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Dinoprostone / antagonists & inhibitors
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Dinoprostone / biosynthesis
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Interleukin-1 / antagonists & inhibitors
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Interleukin-1 / pharmacology
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Mandible / drug effects
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Mandible / metabolism
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Mandible / pathology
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Mice
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Organ Culture Techniques
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Osteoclasts / drug effects*
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Osteoclasts / metabolism
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Osteoclasts / pathology
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Skull / drug effects
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Skull / metabolism
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Skull / pathology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Flavonoids
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Interleukin-1
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Lipopolysaccharides
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3,3',4',5,6,7,8-heptamethoxyflavone
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Dinoprostone