A coinfection model for HIV and HCV

Ana R M Carvalho; Carla M A Pinto

doi:10.1016/j.biosystems.2014.08.004

A coinfection model for HIV and HCV

Biosystems. 2014 Oct:124:46-60. doi: 10.1016/j.biosystems.2014.08.004. Epub 2014 Aug 28.

Authors

Ana R M Carvalho¹, Carla M A Pinto²

Affiliations

¹ Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4440-452 Porto, Portugal. Electronic address: up200802541@fc.up.pt.
² School of Engineering, Polytechnic of Porto, and Centre for Mathematics of the University of Porto, Rua Dr António Bernardino de Almeida, 431, 4200-072 Porto, Portugal. Electronic address: cap@isep.ipp.pt.

PMID: 25174999
DOI: 10.1016/j.biosystems.2014.08.004

Abstract

We study a mathematical model for the human immunodeficiency virus (HIV) and hepatites C virus (HCV) coinfection. The model predicts four distinct equilibria: the disease free, the HIV endemic, the HCV endemic, and the full endemic equilibria. The local and global stability of the disease free equilibrium was calculated for the full model and the HIV and HCV submodels. We present numerical simulations of the full model where the distinct equilibria can be observed. We show simulations of the qualitative changes of the dynamical behavior of the full model for variation of relevant parameters. From the results of the model, we infer possible measures that could be implemented in order to reduce the number of infected individuals.

Keywords: Coinfection; HCV; HIV/AIDS; Mathematical model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

HIV Infections / complications*
Hepatitis C / complications*
Humans
Models, Theoretical