A helminth-mediated viral awakening

Trends Immunol. 2014 Oct;35(10):452-3. doi: 10.1016/j.it.2014.08.004. Epub 2014 Aug 28.

Abstract

Co-infections may have unpredictable consequences for the health of a host beyond the sum of the individual infections. Two recent papers in Science provide mechanistic insights into how acute helminth infections alter the outcome of Herpesvirus and Norovirus infections by triggering changes in the local cytokine environment.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caliciviridae Infections / immunology*
  • Coinfection / immunology*
  • Gammaherpesvirinae / physiology*
  • Gastroenteritis / immunology*
  • Herpesvirus 8, Human / physiology*
  • Humans
  • Immunomodulation*
  • Interferon-gamma / immunology*
  • Interleukin-4 / metabolism*
  • Lectins / immunology*
  • Microbiota / immunology*
  • Norovirus / immunology*
  • STAT6 Transcription Factor / metabolism*
  • Schistosoma mansoni / immunology*
  • Schistosomiasis mansoni / immunology*
  • Trichinella / immunology*
  • Trichinellosis / immunology*
  • Virus Activation / physiology*
  • beta-N-Acetylhexosaminidases / immunology*

Substances

  • Lectins
  • STAT6 Transcription Factor
  • Interleukin-4
  • Interferon-gamma
  • beta-N-Acetylhexosaminidases