Abstract
Co-infections may have unpredictable consequences for the health of a host beyond the sum of the individual infections. Two recent papers in Science provide mechanistic insights into how acute helminth infections alter the outcome of Herpesvirus and Norovirus infections by triggering changes in the local cytokine environment.
Copyright © 2014 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Caliciviridae Infections / immunology*
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Coinfection / immunology*
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Gammaherpesvirinae / physiology*
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Gastroenteritis / immunology*
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Herpesvirus 8, Human / physiology*
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Humans
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Immunomodulation*
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Interferon-gamma / immunology*
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Interleukin-4 / metabolism*
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Lectins / immunology*
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Microbiota / immunology*
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Norovirus / immunology*
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STAT6 Transcription Factor / metabolism*
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Schistosoma mansoni / immunology*
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Schistosomiasis mansoni / immunology*
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Trichinella / immunology*
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Trichinellosis / immunology*
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Virus Activation / physiology*
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beta-N-Acetylhexosaminidases / immunology*
Substances
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Lectins
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STAT6 Transcription Factor
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Interleukin-4
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Interferon-gamma
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beta-N-Acetylhexosaminidases