Brucella abortus DNA is a major bacterial agonist to activate the host innate immune system

Microbes Infect. 2014 Dec;16(12):979-84. doi: 10.1016/j.micinf.2014.08.010. Epub 2014 Aug 27.

Abstract

Immunity against Brucella abortus depends on the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). Signaling pathways triggered by Brucella DNA involves TLR9, AIM2 and possibly STING and MAVS. Herein, we review the advances in B. abortus DNA sensing by host innate immune receptors and the progress in this field.

Keywords: Bacterial DNA; Brucella abortus; Cytosolic sensors; Innate immunity; TLRs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brucella abortus / genetics
  • Brucella abortus / immunology*
  • Brucellosis / genetics
  • Brucellosis / immunology
  • Brucellosis / metabolism
  • Cytosol / metabolism
  • DNA, Bacterial / genetics
  • DNA, Bacterial / immunology*
  • Endosomes / metabolism
  • Host-Pathogen Interactions / genetics
  • Host-Pathogen Interactions / immunology*
  • Humans
  • Immunity, Innate / physiology*
  • Signal Transduction
  • Toll-Like Receptor 9 / genetics
  • Toll-Like Receptor 9 / metabolism

Substances

  • DNA, Bacterial
  • Toll-Like Receptor 9