Abstract
Immunity against Brucella abortus depends on the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). Signaling pathways triggered by Brucella DNA involves TLR9, AIM2 and possibly STING and MAVS. Herein, we review the advances in B. abortus DNA sensing by host innate immune receptors and the progress in this field.
Keywords:
Bacterial DNA; Brucella abortus; Cytosolic sensors; Innate immunity; TLRs.
Copyright © 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Brucella abortus / genetics
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Brucella abortus / immunology*
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Brucellosis / genetics
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Brucellosis / immunology
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Brucellosis / metabolism
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Cytosol / metabolism
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DNA, Bacterial / genetics
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DNA, Bacterial / immunology*
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Endosomes / metabolism
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Host-Pathogen Interactions / genetics
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Host-Pathogen Interactions / immunology*
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Humans
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Immunity, Innate / physiology*
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Signal Transduction
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Toll-Like Receptor 9 / genetics
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Toll-Like Receptor 9 / metabolism
Substances
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DNA, Bacterial
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Toll-Like Receptor 9