Emerging roles of RNA modification: m(6)A and U-tail

Mihye Lee; Boseon Kim; V Narry Kim

doi:10.1016/j.cell.2014.08.005

Emerging roles of RNA modification: m(6)A and U-tail

Cell. 2014 Aug 28;158(5):980-987. doi: 10.1016/j.cell.2014.08.005.

Authors

Mihye Lee¹, Boseon Kim¹, V Narry Kim²

Affiliations

¹ IBS Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.
² IBS Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. Electronic address: narrykim@snu.ac.kr.

PMID: 25171402
DOI: 10.1016/j.cell.2014.08.005

Abstract

Although more than 100 types of RNA modification have been described thus far, most of them were thought to be rare in mRNAs and in regulatory noncoding RNAs. Recent developments have unveiled that at least some of the modifications are considerably abundant and widely conserved. This Minireview summarizes the molecular machineries and biological functions of methylation (N6-methyladenosine, m(6)A) and uridylation (U-tail).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Methylation
MicroRNAs / metabolism
Nucleotidyltransferases / metabolism
RNA Processing, Post-Transcriptional*
RNA, Messenger / metabolism*
Uridine Monophosphate / metabolism

Substances

MicroRNAs
RNA, Messenger
Uridine Monophosphate
Nucleotidyltransferases