Inhibition of rat lens aldose reductase by bendazac-L-lysine salt

Enzyme. 1989;42(4):235-7. doi: 10.1159/000469037.

Abstract

Authors describe the in vitro effect of bendazac-L-lysine salt on the activity of enzyme aldose reductase from rat lens. In the presence of bendazac the activity of the tested enzyme was inhibited. Lineweaver-Burk plot demonstrated that the inhibition was noncompetitive. The possible curative effects on diabetic cataract together with a better way of administration are pointed out.

MeSH terms

  • Aldehyde Reductase / antagonists & inhibitors*
  • Animals
  • Cataract / prevention & control
  • Indazoles / pharmacology*
  • Kinetics
  • Lens, Crystalline / enzymology*
  • Pyrazoles / pharmacology*
  • Rats
  • Sugar Alcohol Dehydrogenases / antagonists & inhibitors*

Substances

  • Indazoles
  • Pyrazoles
  • bendazac lysine
  • Sugar Alcohol Dehydrogenases
  • Aldehyde Reductase