Enantiopure isoindolinones through Viedma ripening

Abstract

Here we demonstrate that deracemization of isoindolinones using Viedma ripening is possible starting from a racemic mixture of conglomerate crystals. Crystals of the enantiopure isoindolinones lose their chiral identity upon dissolution even without the need for a catalyst. This enabled complete deracemization of the reported isoindolinones without a catalyst.

Keywords: asymmetric amplification; chiral resolution; chirality; grinding; heterocycles.