Injectable smart phase-transformation implants for highly efficient in vivo magnetic-hyperthermia regression of tumors

Adv Mater. 2014 Nov 26;26(44):7468-73. doi: 10.1002/adma.201402509. Epub 2014 Aug 28.

Abstract

A minimally invasive, highly efficient and versatile strategy is proposed for localized tumor regression by developing a smart injectable liquid-solid phase-transformation organic-inorganic hybrid composite material, i.e., magnetic-Fe-powder-dispersed PLGA (Fe/PLGA) implants for magnetic hyperthermia therapy of cancer.

Keywords: PLGA; cancer therapy; implant; magnetic ablation; phase transformation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ablation Techniques / instrumentation
  • Ablation Techniques / methods
  • Adenocarcinoma / pathology
  • Adenocarcinoma / therapy*
  • Animals
  • Humans
  • Hyperthermia, Induced* / instrumentation
  • Hyperthermia, Induced* / methods
  • Lactic Acid / administration & dosage
  • Lactic Acid / chemistry
  • MCF-7 Cells
  • Magnetic Fields*
  • Magnetite Nanoparticles / administration & dosage*
  • Magnetite Nanoparticles / chemistry
  • Mice, Nude
  • Microscopy, Electron, Transmission
  • Necrosis / pathology
  • Neoplasm Transplantation
  • Phase Transition
  • Polyglycolic Acid / administration & dosage
  • Polyglycolic Acid / chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Powders
  • Sodium Chloride / chemistry
  • Temperature
  • Tumor Burden
  • Ultrasonography

Substances

  • Magnetite Nanoparticles
  • Powders
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Sodium Chloride