Semiempirical model for the ion impact ionization of complex biological media

Phys Rev Lett. 2013 Apr 5;110(14):148104. doi: 10.1103/PhysRevLett.110.148104. Epub 2013 Apr 5.

Abstract

We present a semiempirical model for calculating the electron emission from any organic compound after ion impact. With only the input of the density and composition of the target we are able to evaluate its ionization cross sections using plausible approximations. Results for protons impacting in the most representative biological targets (such as water or DNA components) show a very good comparison with experimental data. Because of its simplicity and great predictive effectiveness, the method can be immediately extended to any combination of biological target and charged particle of interest in ion beam cancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • DNA Damage
  • Heavy Ion Radiotherapy
  • Models, Biological*
  • Neoplasms / radiotherapy
  • Proton Therapy
  • Protons*
  • Water / chemistry*

Substances

  • Protons
  • Water
  • DNA