Cyclometalated gold(III) complexes for chemoselective cysteine modification via ligand controlled C-S bond-forming reductive elimination

Chem Commun (Camb). 2014 Oct 14;50(80):11899-902. doi: 10.1039/c4cc04467c.

Abstract

Modular assembly of cyclometalated gold(III) complexes by choosing appropriate bidentate C,N-donor ligands and ancillary ligands for chemoselective cysteine modification of peptides and proteins via C-S bond-forming reductive elimination has been achieved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cattle
  • Cysteine / chemistry*
  • Humans
  • Ligands
  • Models, Molecular
  • Molecular Sequence Data
  • Organogold Compounds / chemistry*
  • Oxidation-Reduction
  • Peptides / chemistry*
  • Serum Albumin / chemistry*
  • Serum Albumin, Bovine / chemistry*

Substances

  • Ligands
  • Organogold Compounds
  • Peptides
  • Serum Albumin
  • Serum Albumin, Bovine
  • Cysteine