Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphellan antipathies

Hsu-Ming Chung; Wei-Hsien Wang; Tsong-Long Hwang; Jan-Jung Li; Lee-Shing Fang; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/molecules190812320

Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphellan antipathies

Molecules. 2014 Aug 14;19(8):12320-7. doi: 10.3390/molecules190812320.

Authors

Hsu-Ming Chung¹, Wei-Hsien Wang², Tsong-Long Hwang³, Jan-Jung Li⁴, Lee-Shing Fang⁵, Yang-Chang Wu⁶, Ping-Jyun Sung⁷

Affiliations

¹ Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan. shiuanmin@mail.npue.edu.tw.
² National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. whw@nmmba.gov.tw.
³ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁴ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. jj@nmmba.gov.tw.
⁵ Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
⁶ School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
⁷ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.

Abstract

Two new 4,5-seco-caryophyllane sesquiterpenoids, rumphellaones B (1) and C (2), which were found to possess unprecedented γ-lactone moieties, were obtained from the gorgonian coral Rumphella antipathies. The structures of 1 and 2 were elucidated by spectroscopic methods and compound 2 was found to display modest inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils at a concentration of 10 μg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification*
Anti-Inflammatory Agents / pharmacology
Cells, Cultured
Humans
Neutrophils / drug effects
Neutrophils / enzymology
Pancreatic Elastase / metabolism
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
Superoxides / metabolism

Substances

Anti-Inflammatory Agents
Sesquiterpenes
rumphellaone B
rumphellaone C
Superoxides
Pancreatic Elastase