It has been recognized for decades that proteins, which are encoded by our genome and produced via transcription and translation steps, are building blocks that play vital roles in almost all biological processes. Mutations identified in many protein-coding genes are linked to various human diseases. However, this "protein-centered" dogma has been challenged in recent years with the discovery that the majority of our genome is "non-coding" yet transcribed. Non-coding RNA has become the focus of "next generation" biology. Here, we review the emerging field of non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), and their role in cardiovascular function and disease.