Cell culture of retinal pigment epithelium: Special Issue

Bruce A Pfeffer; Nancy J Philp

doi:10.1016/j.exer.2014.07.010

Cell culture of retinal pigment epithelium: Special Issue

Exp Eye Res. 2014 Sep:126:1-4. doi: 10.1016/j.exer.2014.07.010.

Authors

Bruce A Pfeffer¹, Nancy J Philp²

Affiliations

¹ Veterans Affairs-Western New York Healthcare System, 3495 Bailey Avenue, Building 20, Room 207, NY 14215, USA(2); Ross Eye Institute, Department of Ophthalmology, and Department of Biochemistry, and SUNY Eye Institute, University at Buffalo, USA. Electronic address: brucepfe@buffalo.edu.
² Thomas Jefferson University, Department of Pathology, Anatomy, and Cell Biology, Philadelphia, PA 19107, USA. Electronic address: Nancy.Philp@jefferson.edu.

PMID: 25152358
DOI: 10.1016/j.exer.2014.07.010

Abstract

This series of review articles highlights how in vitro models of RPE can be effectively used to understand essential functions of the RPE that are not only fundamental to epithelial biology, but also have direct relevance to the visual system. The issue contains reviews from experts in the field covering aspects of basic cell and epithelial biology, namely: the barrier properties of the RPE (Rizzolo, 2014), epithelial polarity (Lehmann et al., 2014), cytoskeleton (Bonilha, 2014), and lysosomes (Guha et al., 2014), as well as properties more unique to the RPE, e.g., vitamin A metabolism (Hu and Bok, 2014), bioenergetics (Adijanto and Philp, 2014), phagocytosis (Mazzoni et al., 2014), ion transport (Reichhart and Strauß, 2014), and melanin/lipofuscin (Boulton, 2014).

Keywords: cell culture; cell differentiation; in vitro models; ocular cell lines; retinal pigment epithelium; signature genes; translational ophthalmology.

Publication types

Introductory Journal Article

MeSH terms

Cells, Cultured / physiology
Humans
Models, Biological*
Retinal Pigment Epithelium* / cytology
Retinal Pigment Epithelium* / physiology

Grants and funding

R01 EY012042/EY/NEI NIH HHS/United States