Antimicrobial glycoalkaloids from the tubers of Stephania succifera

Arch Pharm Res. 2017 Apr;40(4):429-434. doi: 10.1007/s12272-014-0467-5. Epub 2014 Aug 23.

Abstract

Three new glycoalkaloids, N-formyl-asimilobine-2-O-β-D-glucoside (1), (-)-1-O-β-D-glucoside-8-oxotetrahydropalmatine (2), and 1-N-monomethylcarbamate-argentinine-3-O-β-D-glucoside (3) were isolated from tubers of Stephania succifera. The structures were established based on spectroscopic analysis, and the antimicrobial activities of the three glycoalkaloids are reported.

Keywords: Alkaloid; Antimicrobial activity; Glycoalkaloid; Stephania succifera.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Candida albicans / drug effects*
  • Dose-Response Relationship, Drug
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Staphylococcus aureus / drug effects*
  • Stephania / chemistry*
  • Structure-Activity Relationship

Substances

  • Alkaloids
  • Anti-Bacterial Agents