Efficient synthesis of aryl boronates via zinc-catalyzed cross-coupling of alkoxy diboron reagents with aryl halides at room temperature

Shubhankar Kumar Bose; Todd B Marder

doi:10.1021/ol502120q

Efficient synthesis of aryl boronates via zinc-catalyzed cross-coupling of alkoxy diboron reagents with aryl halides at room temperature

Org Lett. 2014 Sep 5;16(17):4562-5. doi: 10.1021/ol502120q. Epub 2014 Aug 22.

Authors

Shubhankar Kumar Bose¹, Todd B Marder

Affiliation

¹ Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg , Am Hubland, 97074 Würzburg, Germany.

PMID: 25148202
DOI: 10.1021/ol502120q

Abstract

A zinc(II)/NHC system catalyzes the borylation of aryl halides with diboron (4) reagents in the presence of KOMe at rt. This transformation can be applied to a broad range of substrates with high functional group compatibility. Radical scavenger experiments do not support a radical-mediated process.