Reconstruction of cell-electrode-adjacencies on multielectrode arrays

J Comput Neurosci. 2014 Dec;37(3):583-91. doi: 10.1007/s10827-014-0524-6. Epub 2014 Aug 23.

Abstract

The multichannel recordings of signals of many cells cultivated on a multielectrode array (MEA) impose some challenging problems. A meanwhile classic problem is the separation of the recordings of a single electrode into classes of recordings where each class is caused by a single cell. This is the well-known spike sorting. A "dual" problem is the determination of the set of electrodes that record signals of a single cell. This set is called the neighborhood of the cell and has often more than one element if the MEA has a large number of electrodes with high density. A method for the reconstruction of the neighborhoods from the multichannel recordings is presented. Special effort is directed to a precise peak detection. For the evaluation of the algorithm, artificial data, obtained from an appropriate model of MEA recordings, are used. Because the artificial data provide a ground truth, an evaluation of the accuracy of the algorithm is possible. The algorithm works well for realistic parameters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Algorithms
  • Animals
  • Electrodes*
  • Humans
  • Models, Neurological*
  • Nerve Net / physiology*
  • Neurons / physiology*