The activity of silver nanoparticles (Axonnite) on clinical and environmental strains of Acinetobacter spp

Monika E Łysakowska; Anna Ciebiada-Adamiec; Leszek Klimek; Monika Sienkiewicz

doi:10.1016/j.burns.2014.07.014

The activity of silver nanoparticles (Axonnite) on clinical and environmental strains of Acinetobacter spp

Burns. 2015 Mar;41(2):364-71. doi: 10.1016/j.burns.2014.07.014. Epub 2014 Aug 18.

Authors

Monika E Łysakowska¹, Anna Ciebiada-Adamiec², Leszek Klimek³, Monika Sienkiewicz⁴

Affiliations

¹ Medical and Sanitary Microbiology Department, Medical University of Lodz, pl. Hallera 1, 90-647 Lodz, Poland. Electronic address: monika.lysakowska@umed.lodz.pl.
² Medical Diagnostic Laboratory Center, Polish Mother's Memorial Hospital, 281/289 Rzgowska St., 93-338 Lodz, Poland.
³ Dentistry Technics Department, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland; Institute of Material Science and Engineering, Lodz University of Technology, 1/15 Stefanowskiego St., 90-924, Poland.
⁴ Environmental Biology Department, Medical University of Lodz, 7/9 Zeligowskiego St., 90-752 Lodz, Poland.

PMID: 25145873
DOI: 10.1016/j.burns.2014.07.014

Abstract

Acinetobacter baumannii isolates are responsible for a high number of wound infections. The reason of this study was to evaluate the activity of silver nanoparticles obtained by microexplosion against wide range of Acinetobacter spp. Susceptibility to silver nanoparticles was tested by microdilution method, susceptibility to antibiotics was evaluated by the disc-diffusion method. All strains of Acinetobacter spp. were sensitive to AgNPs at low concentrations. The values of the MIC for strains of Acinetobacter spp. were 0.39 and 0.78μg/mL. In general, strains inhibited by 0.78μg/mL of AgNPs were more resistant to antibiotics than Acinetobacter strains for which MIC=0.39μg/mL (p=0.023). The AgNPs in Axonnite seems to be a good alternative for other antimicrobials to treat wound infections caused by multidrug resistant Acinetobacter spp. strains because of its high activity.

Keywords: Acinetobacter baumannii; AgNPs; Silver nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acinetobacter / drug effects*
Acinetobacter Infections / prevention & control
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Drug Resistance, Multiple, Bacterial / drug effects
Humans
Metal Nanoparticles / chemistry*
Microbial Sensitivity Tests
Silver / pharmacology*

Substances

Anti-Bacterial Agents
Silver