Mixed messages: Re-initiation factors regulate translation of animal mRNAs

Benedikt Obermayer; Nikolaus Rajewsky

doi:10.1038/cr.2014.114

Mixed messages: Re-initiation factors regulate translation of animal mRNAs

Cell Res. 2014 Dec;24(12):1383-4. doi: 10.1038/cr.2014.114. Epub 2014 Aug 22.

Authors

Benedikt Obermayer¹, Nikolaus Rajewsky¹

Affiliation

¹ Max Delbrück Center (MDC) for Molecular Medicine, Robert Rössle Str. 10, 13125 Berlin-Buch, Germany.

Abstract

When ribosomes encounter upstream open reading frames (uORFs) during scanning of the 5' untranslated region (5' UTR), translation of the downstream ORF requires re-initiation. In a recent paper in Nature, Schleich et al. describe metazoan factors which specifically promote re-initiation.

Publication types

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MeSH terms

Animals
Drosophila Proteins / metabolism*
Eukaryotic Initiation Factors / metabolism*
Gene Expression Regulation / genetics*
Protein Biosynthesis / genetics*

Substances

Drosophila Proteins
Eukaryotic Initiation Factors