The making of the master clock

Elife. 2014 Aug 20:3:e04014. doi: 10.7554/eLife.04014.

Authors

Ethan Buhr¹, Russell N Van Gelder²

Affiliations

¹ Ethan Buhr is in the Department of Ophthalmology, University of Washington Medical School, Seattle, United States.
² Russell N Van Gelder is in the Departments of Ophthalmology, Biological Structure, and Pathology, University of Washington Medical School, Seattle, United States russvg@u.washington.edu.

Abstract

A genetic basis for the anatomic master circadian clock in mammals has been found.

Keywords: Lhx1; Ror-alpha; VIP; circadian rhythms; suprachiasmatic nucleus.

Copyright © 2014, Buhr and Van Gelder.

Publication types

Comment

MeSH terms

Animals
Circadian Clocks / genetics*
Jet Lag Syndrome / genetics*
LIM-Homeodomain Proteins / genetics*
Male
Neurons / metabolism*
Period Circadian Proteins / genetics*
Suprachiasmatic Nucleus / metabolism*
Transcription Factors / genetics*

Substances

LIM-Homeodomain Proteins
Lhx1 protein, mouse
Period Circadian Proteins
Transcription Factors