Preparation of highly substituted (β-acylamino)acrylates via iron-catalyzed alkoxycarbonylation of N-vinylacetamides with carbazates

Ran Ding; Qiu-Chi Zhang; Yun-He Xu; Teck-Peng Loh

doi:10.1039/c4cc05338a

Preparation of highly substituted (β-acylamino)acrylates via iron-catalyzed alkoxycarbonylation of N-vinylacetamides with carbazates

Chem Commun (Camb). 2014 Oct 11;50(79):11661-4. doi: 10.1039/c4cc05338a.

Authors

Ran Ding¹, Qiu-Chi Zhang, Yun-He Xu, Teck-Peng Loh

Affiliation

¹ Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. xyh0709@ustc.edu.cn.

PMID: 25141227
DOI: 10.1039/c4cc05338a

Abstract

An efficient iron(II)-catalyzed alkoxycarbonylation reaction between N-vinylacetamides and carbazates is reported. The corresponding useful highly substituted (β-acylamino)acrylates could be obtained in reasonable to good yields and stereoselectivity under mild reaction conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetamides / chemistry*
Acrylates / chemistry*
Catalysis
Ferrous Compounds / chemistry*
Hydrazines / chemistry*
Indoles / chemistry*

Substances

Acetamides
Acrylates
Ferrous Compounds
Hydrazines
Indoles
iron phthalocyanine
carbazic acid