Golgi apparatus: finally mechanics comes to play in the secretory pathway

Gustavo Egea; Carla Serra-Peinado

doi:10.1016/j.cub.2014.07.002

Golgi apparatus: finally mechanics comes to play in the secretory pathway

Curr Biol. 2014 Aug 18;24(16):R741-3. doi: 10.1016/j.cub.2014.07.002.

Authors

Gustavo Egea¹, Carla Serra-Peinado²

Affiliations

¹ Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, and Instituts d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) and de Nanociència I Nanotechnologia (IN(2)UB), Casanova 143, 08036 Barcelona, Spain. Electronic address: gegea@ub.edu.
² Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, and Instituts d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) and de Nanociència I Nanotechnologia (IN(2)UB), Casanova 143, 08036 Barcelona, Spain.

PMID: 25137584
DOI: 10.1016/j.cub.2014.07.002

Abstract

New findings report a mechanical role for actin in Golgi organization and vesicular trafficking. An elegant study uses optical tweezers and live-cell imaging to demonstrate the effects of a mechanical constraint on the dynamics of secretory membrane trafficking, combining physical experimental approaches with in cellulo studies of endomembranes.

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MeSH terms

Golgi Apparatus / metabolism*
Humans
Intracellular Membranes / metabolism*